Document Type
Article
Abstract
Hematopoietic Stem Cells (HSCs) are supported by the bone marrow microenvironment to maintain normal production of blood cells. The niche may be considered an “ecosystem” that support the function of HSCs and other supportive cells. Alterations in the bone marrow niche are commonly observed in hematologic malignancies. Here, we review recent insights into the location and the molecular and cellular components of the bone marrow niche. Moreover, we discuss how the niche interacts with HSCs to drive the pathogenesis of hematopoietic malignancies. Overall, a better understanding of the influences on the HSC niche may drive therapeutic development targeting defective and aberrant hematopoiesis.
Publication Date
9-6-2024
Recommended Citation
Wang, Weiyuan; Brown, Timothy; and Barth, Brian, "Influences on the Hematopoietic Stem Cell Niche" (2024). Faculty, Staff, and Students. 212.
https://ualaska.researchcommons.org/uas_sas_facpubs/212
Handle
http://hdl.handle.net/11122/15714